Melanoma Cell Adhesion Molecule (MCAM) Antibody

The protein encoded by this gene plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue.Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread.Could be an adhesion molecule active in neural crest cells during embryonic development.Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.

Target	Melanoma Cell Adhesion Molecule (MCAM)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC, FCM
Host	Mouse
Recommended dilutions	ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human MCAM (AA: 84-189) expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Purified from ascites by Protein G chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P43121 (UniProt, ExPASy)
UniProt Secondary AC	O95812, Q59E86, Q6PHR3, Q6ZTR2
UniProt Entry Name	MUC18_HUMAN
Gene Symbol	MCAM
GeneID	4162
OMIM	155735
HGNC	6934
KEGG	hsa:4162
Ensembl	ENSG00000076706
String	9606.ENSP00000264036
Molecular Weight	71.6 kDa
Buffer	PBS, containing 0.05% sodium azide.
Concentration	1 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Melanoma Cell Adhesion Molecule (MCAM)

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