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Melanoma Cell Adhesion Molecule (MCAM) Antibody
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Catalogue No: abx015923
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US$427.75
(Size: 100 µl)
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Datasheet SDS
The protein encoded by this gene plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue.Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread.Could be an adhesion molecule active in neural crest cells during embryonic development.Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.
Research Articles on Melanoma Cell Adhesion Molecule (MCAM)
| Target | Melanoma Cell Adhesion Molecule (MCAM) |
| Research Area | Cytokines, Tumor Immunity, Infection Immunity, Cancer |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC, FCM |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of human MCAM (AA: 84-189) expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Purified from ascites by Protein G chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P43121 (UniProt, ExPASy) |
| UniProt Secondary AC | O95812, Q59E86, Q6PHR3, Q6ZTR2 |
| UniProt Entry Name | MUC18_HUMAN |
| Gene Symbol | MCAM |
| GeneID | 4162 |
| OMIM | 155735 |
| HGNC | 6934 |
| KEGG | hsa:4162 |
| Ensembl | ENSG00000076706 |
| String | 9606.ENSP00000264036 |
| Molecular Weight | 71.6 kDa |
| Buffer | PBS, containing 0.05% sodium azide. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |