MCM10 Minichromosome Maintenance Deficient 10 (MCM10) Antibody

MCM10 Antibody is a Rabbit Polyclonal antibody against MCM10. The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified.

Target	MCM10 Minichromosome Maintenance Deficient 10 (MCM10)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 616-875 of human MCM10.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q7L590 (UniProt, ExPASy)
UniProt Entry Name	MCM10_HUMAN
Gene Symbol	MCM10
GeneID	55388
NCBI Accession	NP_877428.1
KEGG	hsa:55388
String	9606.ENSP00000418268
Molecular Weight	Calculated MW: 98 kDa Observed MW: 125 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on MCM10 Minichromosome Maintenance Deficient 10 (MCM10)

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