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DNA Replication Licensing Factor MCM2 (MCM2) Antibody
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Catalogue No: abx034344
Price:
US$326.25
(Size: 80 µl)
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Datasheet SDS
MCM2 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7.
Research Articles on DNA Replication Licensing Factor MCM2 (MCM2)
| Target | DNA Replication Licensing Factor MCM2 (MCM2) |
| Research Area | Developmental Science |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/2000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 649-677 amino acids from the C-terminal region of human MCM2. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P49736 (UniProt, ExPASy) |
| UniProt Secondary AC | Q14577, Q15023, Q8N2V1, Q969W7, Q96AE1, Q9BRM7 |
| UniProt Entry Name | MCM2_HUMAN |
| KEGG | hsa:4171 |
| String | 9606.ENSP00000265056 |
| Molecular Weight | Calculated MW: 102 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Xenopus MCM2. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |