DNA Replication Licensing Factor MCM2 (MCM2) Antibody

MCM2 Antibody is a Rabbit Polyclonal antibody against MCM2. The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined.

Target	DNA Replication Licensing Factor MCM2 (MCM2)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 360-700 of human MCM2.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P49736 (UniProt, ExPASy)
UniProt Secondary AC	Q14577, Q15023, Q8N2V1, Q969W7, Q96AE1, Q9BRM7
UniProt Entry Name	MCM2_HUMAN
Gene Symbol	MCM2
GeneID	4171
NCBI Accession	NP_004517.2
KEGG	hsa:4171
String	9606.ENSP00000265056
Molecular Weight	Calculated MW: 102 kDa Observed MW: 130 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on DNA Replication Licensing Factor MCM2 (MCM2)

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