Minichromosome Maintenance Deficient 3 (MCM3) Antibody

MCM3 Antibody is a Rabbit Polyclonal antibody against MCM3. The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been found for this gene.

Target	Minichromosome Maintenance Deficient 3 (MCM3)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IP
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IP: 0.5-4 µg/200-400 µg whole cell extracts. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 1-295 of human MCM3.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P25205 (UniProt, ExPASy)
UniProt Secondary AC	B4DWW4, Q92660, Q9BTR3, Q9NUE7
UniProt Entry Name	MCM3_HUMAN
Gene Symbol	MCM3
GeneID	4172
NCBI Accession	NP_002379.2
KEGG	hsa:4172
String	9606.ENSP00000480987
Molecular Weight	Calculated MW: 91 kDa Observed MW: 105 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Minichromosome Maintenance Deficient 3 (MCM3)

Write a review

Your Name

Your Email Address

PMID

DOI

Your Review

Rating

Continue