Minichromosome Maintenance Deficient 7 (MCM7) Antibody

MCM7 Antibody is a Rabbit Polyclonal antibody against MCM7. The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Target	Minichromosome Maintenance Deficient 7 (MCM7)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	WB, IF/ICC, IP
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000, IF/ICC: 1/50 - 1/200, IP: 0.5-4 µg/200-400 µg whole cell extracts. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human MCM7.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P33993 (UniProt, ExPASy)
UniProt Secondary AC	A4D2A1, A4D2A2, E9PGN9, Q15076, Q96D34, Q96GL1
UniProt Entry Name	MCM7_HUMAN
Gene Symbol	MCM7
GeneID	4176
NCBI Accession	NP_005907.3
KEGG	hsa:4176
String	9606.ENSP00000307288
Molecular Weight	Calculated MW: 81 kDa Observed MW: 81 kDa
Buffer	PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Minichromosome Maintenance Deficient 7 (MCM7)

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