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Minichromosome Maintenance Deficient 7 (MCM7) Antibody
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Catalogue No: abx001052
Price:
£120.00
(Size: 20 µl)
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MCM7 Antibody is a Rabbit Polyclonal antibody against MCM7. The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Research Articles on MCM7
| Target | MCM7 |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | WB, IF/ICC, IP |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200, IP: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant protein of human MCM7. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P33993 (UniProt, ExPASy) |
| UniProt Secondary AC | A4D2A1, A4D2A2, E9PGN9, Q15076, Q96D34, Q96GL1 |
| UniProt Entry Name | MCM7_HUMAN |
| Gene Symbol | MCM7 |
| GeneID | 4176 |
| KEGG | hsa:4176 |
| String | 9606.ENSP00000307288 |
| Molecular Weight | Calculated MW: 44 kDa, 60 kDa, 81 kDa Observed MW: 81 kDa |
| Buffer | PBS, pH 7.3, 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.5 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |
