C-C Motif Chemokine 2 / MCP1 (CCL2) Antibody
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Catalogue No: abx011184
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US$427.75
(Size: 100 µl)
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Datasheet SDS
Monocyte chemoattractant protein-1 (CCL2) is a member of the chemokine beta family of cytokines. The protein is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. It may play a inprotant role in the initiation and/or progression of pulmonary hypertension (PH). Blockade of a systemic CCL2 signal pathway in vivo may prevent PH.
Research Articles on C-C Motif Chemokine 2 / MCP1 (CCL2)
| Target | C-C Motif Chemokine 2 / MCP1 (CCL2) |
| Research Area | Enzymes and Kinases, Metabolic Pathways, Tumor Immunity, Cardiovascular Biology, Neuroscience, Cancer |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of human MCP-1 expressed in E. coli. |
| Isotype | IgG1 Kappa |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P13500 (UniProt, ExPASy) |
| UniProt Secondary AC | B2R4V3, Q9UDF3 |
| UniProt Entry Name | CCL2_HUMAN |
| Gene Symbol | CCL2 |
| GeneID | 6347 |
| OMIM | 158105 |
| NCBI Accession | NP_002973.1 NM_002982.3 |
| HGNC | 10618 |
| KEGG | hsa:6347 |
| Ensembl | ENSG00000108691 |
| String | 9606.ENSP00000225831 |
| Molecular Weight | 13 kDa |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |