MDM2 (pS166) Antibody

Catalogue No: abx000146
Price: £50.00
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MDM2 (pS166) Antibody
MDM2 (pS166) Antibody

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MDM2 (pS166) Antibody is a Rabbit Polyclonal antibody against MDM2 (pS166). This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.

Target MDM2 (pS166)
Reactivity Human, Mouse, Rat
Origin Human
Host Rabbit
Clonality Polyclonal
Tested Applications WB, IF/ICC
Recommended dilutions WB: 1/500 - 1/1000, IHC: 1/50 - 1/100, IF/ICC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user.
Immunogen Synthetic Peptide. A phospho specific peptide corresponding to residues surrounding S166 of human MDM2.
Purification Affinity purified.
Isotype IgG
Conjugation Unconjugated
Storage Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
Molecular Weight 55 kDa
Swiss Prot Q00987
GeneID 4193
Gene Symbol MDM2
Concentration > 1 mg/ml
Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Availability Shipped within 5-10 working days.
Note This product is for research use only.

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