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Methyl CpG Binding Protein 2 Phospho-Ser292 (MECP2 pS292) Antibody
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Catalogue No: abx031876
Price:
US$326.25
(Size: 80 µl)
Orders to United States ship from United States
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DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of some cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.
Research Articles on Methyl CpG Binding Protein 2 Phospho-Ser292 (MECP2 pS292)
| Target | Methyl CpG Binding Protein 2 Phospho-Ser292 (MECP2 pS292) |
| Clonality | Polyclonal |
| Target Modification | Ser292 |
| Modification | Phosphorylation |
| Reactivity | Human |
| Tested Applications | ELISA, IHC |
| Host | Rabbit |
| Recommended dilutions | IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S292 of human MECP2. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by protein G affinity chromatography. Then, the antibody fraction was peptide affinity purified in a 2-step procedure with control and phosphorylated peptides. The phospho-specific antibody was eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P51608 (UniProt, ExPASy) |
| UniProt Secondary AC | O15233, Q6QHH9, Q7Z384 |
| UniProt Entry Name | MECP2_HUMAN |
| Gene Symbol | MECP2 |
| GeneID | 4204 |
| OMIM | 105830 |
| HGNC | 6990 |
| KEGG | hsa:4204 |
| Ensembl | ENSG00000169057 |
| String | 9606.ENSP00000395535 |
| Molecular Weight | Calculated MW: 52.4 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse MECP2. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |