Methyl CpG Binding Protein 2 Phospho-Ser423 (MECP2 pS423) Antibody
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Catalogue No: abx032076
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US$326.25
(Size: 80 µl)
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Datasheet SDS
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of some cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.
Research Articles on Methyl CpG Binding Protein 2 Phospho-Ser423 (MECP2 pS423)
| Target | Methyl CpG Binding Protein 2 Phospho-Ser423 (MECP2 pS423) |
| Clonality | Polyclonal |
| Target Modification | Ser423 |
| Modification | Phosphorylation |
| Reactivity | Human, Rat |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500, IHC-P: 1/500. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S423 of human MeCP2. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by two-step phosphospecific peptide affinity purification. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P51608 (UniProt, ExPASy) |
| UniProt Secondary AC | O15233, Q6QHH9, Q7Z384 |
| UniProt Entry Name | MECP2_HUMAN |
| Gene Symbol | MECP2 |
| GeneID | 4204 |
| OMIM | 105830 |
| NCBI Accession | NP_001104262.1 NP_004983.1 |
| HGNC | 6990 |
| KEGG | hsa:4204 |
| Ensembl | ENSG00000169057 |
| String | 9606.ENSP00000395535 |
| Molecular Weight | Calculated MW: 52.4 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse and Monkey MECP2. |
| Concentration | 0.5 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |