Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 (MEK1) Antibody

MAP2K1 is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.

Target	Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 (MEK1)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human MEK1 (MAP2K1).
Isotype	IgG
Form	Liquid
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q02750 (UniProt, ExPASy)
UniProt Entry Name	MP2K1_HUMAN
KEGG	hsa:5604
String	9606.ENSP00000302486
Molecular Weight	Calculated MW: 43.4 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Rat and Rabbit MAP2K1.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 (MEK1)

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