MEK1 (pS218 / 222) Antibody

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Catalogue No: abx031877
Price: US$326.25
(Size: 80 µl)

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Datasheet SDS
MEK1is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. The inhibition or degradation of this kinase is found to be involved in the pathogenesis of Yersinia and anthrax.

Target MEK1 (pS218/222)
Clonality Polyclonal
Target Modification Ser218/222
Modification Phosphorylation
Reactivity Human
Tested Applications ELISA, WB, IHC, DB
Host Rabbit
Recommended dilutions WB: 1/500, IHC-P: 1/50 - 1/100, DB: 1/500. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S218/222 of human MEK1.
Isotype IgG
Form Liquid
Purification Purified by protein G affinity chromatography. Then, the antibody fraction was peptide affinity purified in a 2-step procedure with control and phosphorylated peptides. The phospho-specific antibody was eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q02750 (UniProt, ExPASy)
UniProt Entry Name MP2K1_HUMAN
KEGG hsa:5604
String 9606.ENSP00000302486
Molecular Weight Calculated MW: 43.4 kDa
Buffer PBS containing 0.09% sodium azide.
Specificity Predicted to react with Mouse, Rat, Hamster, Drosophila, Xenopus and C. elegans MAP2K1.
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on MEK1 (pS218/222)


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