Tyrosine-Protein Kinase Mer (MERTK) Antibody

MER (c-mer proto-oncogene tyrosine kinase) is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain.MER has been identified as a tyrosine kinase potentially involved in the development of glioblastomas.It is expressed at highest levels in ovary, prostate, lung and kidney.Gas6, a growth arrest specific gene, and the related anticoagulation factor Protein S have been identified as ligands for the UFO family of receptors.Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).

Target	Tyrosine-Protein Kinase Mer (MERTK)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA
Host	Mouse
Recommended dilutions	ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of MER expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q12866 (UniProt, ExPASy)
UniProt Secondary AC	Q9HBB4
UniProt Entry Name	MERTK_HUMAN
Gene Symbol	MERTK
GeneID	10461
OMIM	604705
NCBI Accession	NP_006334.2
HGNC	7027
KEGG	hsa:10461
Ensembl	ENSG00000153208
String	9606.ENSP00000295408
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Tyrosine-Protein Kinase Mer (MERTK)

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