Metabotropic Glutamate Receptor 3 Antibody

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 (also known as GPRC1C) while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The activity of GRM3 is mediated by a G-protein that inhibits adenylate cyclase activity.

Target	Metabotropic Glutamate Receptor 3
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 828-857 amino acids from the C-terminal region of human Metabotropic Glutamate Receptor 3.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q14832 (UniProt, ExPASy)
UniProt Secondary AC	Q2PNZ6, Q75MV4, Q75N17, Q86YG6, Q8TBH9
UniProt Entry Name	GRM3_HUMAN
KEGG	hsa:2913
String	9606.ENSP00000355316
Molecular Weight	Calculated MW: 98.9 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Monkey GRM3.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Metabotropic Glutamate Receptor 3

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