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Metastasis-Associated Protein MTA2 (MTA2) Antibody

Catalogue No: abx001830
Price: £120.00
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Metastasis-Associated Protein MTA2 (MTA2) Antibody

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MTA2 Antibody is a Rabbit Polyclonal antibody against MTA2. This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis.

Target MTA2
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB, IHC, FCM
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human MTA2.
Isotype IgG
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC O94776 (UniProt, ExPASy)
UniProt Secondary AC Q68DB1, Q9UQB5
UniProt Entry Name MTA2_HUMAN
GeneID 9219
KEGG hsa:9219
String 9606.ENSP00000278823
Molecular Weight 75 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Metastasis-Associated Protein MTA2 (MTA2) Antibody

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