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Hepatocyte Growth Factor Receptor / HGFR (MET) Antibody
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Catalogue No: abx025146
Price:
US$326.25
(Size: 80 µl)
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Hepatocyte Growth Factor Receptor / HGFR (MET) antibody is a Mouse monoclonal against Hepatocyte Growth Factor Receptor / HGFR (MET). Hepatocyte Growth Factor Receptor / HGFR (MET) is a receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/ HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including RAS-ERK, PI3 kinase-AKT and PLCgamma-PKC. RAS-ERK activation is associated with morphogenesis while PI3K/AKT promotes cell survival. During embryonic development, MET signaling plays a role in gastrulation, development and migration of neuronal precursors, angiogenesis and kidney formation. During skeletal muscle development, it is crucial for the migration of muscle progenitor cells and for the proliferation of secondary myoblasts. In adults, it participates in wound healing, organ regeneration and tissue remodeling, along with promoting the proliferation of hematopoietic cells.
Research Articles on Hepatocyte Growth Factor Receptor / HGFR (MET)
| Target | Hepatocyte Growth Factor Receptor / HGFR (MET) |
| Research Area | Tumor Immunity |
| Clonality | Monoclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB, IF/ICC |
| Host | Mouse |
| Recommended dilutions | WB: 1/500 - 1/1000, IF/ICC: 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant protein encoding the catalytic domain of Human MET/HGFR. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Purified through a protein G column, followed by dialysis against PBS. |
| Storage | Store at 2-8°C for up to 2 weeks. Aliquot and store at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P08581 (UniProt, ExPASy) |
| UniProt Secondary AC | A1L467, B5A932, E7EQ94, O60366, Q12875, Q9UDX7, Q9UPL8 |
| Molecular Weight | Calculated MW: 156 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Concentration | 0.5 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |