O-6-Methylguanine DNA Methyltransferase (MGMT) Antibody
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Catalogue No: abx147078
Price:
US$420.50
(Size: 100 µg)
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Datasheet SDS
O-6-Methylguanine DNA Methyltransferase (MGMT) Antibody is a Rabbit Polyclonal antibody for the detection of MGMT. Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
Research Articles on O-6-Methylguanine DNA Methyltransferase (MGMT)
| Target | O-6-Methylguanine DNA Methyltransferase (MGMT) |
| Research Area | Signal Transduction, Enzymes and Kinases, Tumor Immunity, Cancer |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, IHC |
| Host | Rabbit |
| Recommended dilutions | IHC: 1/50 - 1/500. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | O-6-methylguanine-DNA methyltransferase |
| Isotype | IgG |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P16455 (UniProt, ExPASy) |
| UniProt Secondary AC | Q5VY78 |
| UniProt Entry Name | MGMT_HUMAN |
| Gene Symbol | MGMT |
| GeneID | 4255 |
| OMIM | 156569 |
| HGNC | 7059 |
| KEGG | hsa:4255 |
| Ensembl | ENSG00000170430 |
| String | 9606.ENSP00000302111 |
| Enzyme Commission Number | EC 2.1.1.63 |
| Molecular Weight | Observed MW: 22 kDa |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |