O-6-Methylguanine DNA Methyltransferase (MGMT) Antibody
REQUEST MORE INFO
Catalogue No: abx034911
Price:
US$326.25
(Size: 80 µl)
Orders to United States ship from United States
(
Click on the image to see the image legend
Add to Cart
Buy It Now
GET A QUOTE
Documents
Datasheet SDS
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
Research Articles on O-6-Methylguanine DNA Methyltransferase (MGMT)
| Target | O-6-Methylguanine DNA Methyltransferase (MGMT) |
| Research Area | Signal Transduction, Enzymes and Kinases, Tumor Immunity, Cancer |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Host | Mouse |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/25 - 1/100, IF/ICC: 1/25. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified His-tagged Human MGMT protein |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P16455 (UniProt, ExPASy) |
| UniProt Secondary AC | Q5VY78 |
| UniProt Entry Name | MGMT_HUMAN |
| KEGG | hsa:4255 |
| String | 9606.ENSP00000302111 |
| Molecular Weight | Calculated MW: 21.6 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |