O-6-Methylguanine DNA Methyltransferase (MGMT) Antibody

Catalogue No: abx000535
Price: £120.00
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O-6-Methylguanine DNA Methyltransferase (MGMT) Antibody

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MGMT Antibody is a Rabbit Polyclonal antibody against MGMT. MGMT is the primary vehicle for cellular removal of alkyl lesions from the O-6 position of guanine and the O-4 position of thymine. While key to the maintenance of genomic integrity, MGMT also removes damage induced by alkylating chemotherapies, inhibiting the efficacy of cancer treatment [PMID:23065697].MGMT is the primary mechanism for the removal of alkylation damage from the O-6 position of guanine [PMID: 17482892]. The O-6 position of guanine is one of several positions in DNA bases to which alkyl groups are attached in SN1 alkylation reactions, and this repair has been well-characterized in mammalian cells and via MGMT homologs in bacteria and Archaea.[PMID: 10767620].

Target MGMT
Clonality Polyclonal
Reactivity Human
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human MGMT.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P16455 (UniProt, ExPASy)
UniProt Secondary AC Q5VY78
UniProt Entry Name MGMT_HUMAN
Gene Symbol MGMT
GeneID 4255
KEGG hsa:4255
String 9606.ENSP00000302111
Molecular Weight Calculated MW: 21 kDa
Observed MW: 22 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on O-6-Methylguanine DNA Methyltransferase (MGMT) Antibody

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