MHC Class I Polypeptide Related Sequence A (MICA) Antibody

MICA Antibody is a Rabbit Polyclonal antibody against MICA. MICA and MICB are stress-induced antigens that are related to major histocompatibility complex (MHC) class I molecules. MICA and MICB are frequently expressed in epithelial tumors. These highly glycosylated cell surface proteins are stably expressed without conventional class I peptide ligands or association with b-2-Microglobulin. The expression is induced on proliferating or heat shock-stressed epithelial cells. MICA and MICB are broadly recognized by intestinal epithelial Vd1 gd T cells expressing variable TCRs, suggesting that these antigens may play a central role in the signaling of cellular distress to evoke immune responses in the intestinal epithelium.

Target	MHC Class I Polypeptide Related Sequence A (MICA)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 24-307 of human MICA.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q29983 (UniProt, ExPASy)
UniProt Entry Name	MICA_HUMAN
Gene Symbol	MICA
GeneID	4276
NCBI Accession	NP_000238.1
KEGG	hsa:100507436
String	9606.ENSP00000413079
Molecular Weight	Calculated MW: 43 kDa Observed MW: 43 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on MHC Class I Polypeptide Related Sequence A (MICA)

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