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MHC Class I Polypeptide Related Sequence A (MICA) Antibody

Catalogue No: abx001216
Price: £120.00
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MICA Antibody is a Rabbit Polyclonal antibody against MICA. MICA and MICB are stress-induced antigens that are related to major histocompatibility complex (MHC) class I molecules. MICA and MICB are frequently expressed in epithelial tumors. These highly glycosylated cell surface proteins are stably expressed without conventional class I peptide ligands or association with b-2-Microglobulin. The expression is induced on proliferating or heat shock-stressed epithelial cells. MICA and MICB are broadly recognized by intestinal epithelial Vd1 gd T cells expressing variable TCRs, suggesting that these antigens may play a central role in the signaling of cellular distress to evoke immune responses in the intestinal epithelium.

Target MICA
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human MICA.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q29983 (UniProt, ExPASy)
UniProt Entry Name MICA_HUMAN
Gene Symbol MICA
GeneID 4276
String 9606.ENSP00000413079
Molecular Weight Calculated MW: 31 kDa, 42 kDa
Observed MW: 43 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on MHC Class I Polypeptide Related Sequence A (MICA) Antibody

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