Macrophage Migration Inhibitory Factor (MIF) Antibody

Catalogue No: abx001217
Price: £120.00
(Size: 20 µl)
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MIF Antibody is a Rabbit Polyclonal antibody against MIF. Macrophage migration inhibitory factor, known as MIF or glycosylation-inhibiting factor, is a secreted, homotrimeric, pro-inflammatory cytokine that modulates macrophage and T cell function and is an important regulator of host response to infection. MIF is expressed at sites of inflammation, which suggests that it plays a role in regulating macrophage function in host defense. MIF is produced by the pituitary gland and is found in monocytes, macrophages, differentiating immunological cells in the eye lens and brain, and fibroblasts. Elevated levels of MIF protein are detected in the plasma of patients with severe sepsis or septic shock, a condition where MIF influences endotoxic shock by enhancing the production of other inflammatory cytokines including tumor necrosis factor å (TNFå), interleukin-1 (IL-1) and interferon-© (IFN-©). MIF promotes the systemic inflammatory response by counter-regulating glucocorticoid-mediated inhibition of immune-cell activation and proinflammatory cytokine production. MIF may mediate tissue destruction through the induction of proteinases.

Target MIF
Clonality Polyclonal
Reactivity Human, Mouse
Tested Applications WB, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IF/ICC: 1/10 - 1/100. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human MIF.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P14174 (UniProt, ExPASy)
UniProt Secondary AC A5Z1R8, B2R4S3, Q2V4Y5, Q6FHV0
UniProt Entry Name MIF_HUMAN
Gene Symbol MIF
GeneID 4282
KEGG hsa:4282
String 9606.ENSP00000215754
Molecular Weight Calculated MW: 12 kDa
Observed MW: 12 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Macrophage Migration Inhibitory Factor (MIF) Antibody

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