Mitogen-Activated Protein Kinase Kinase Kinase 3 (MAP3K3) Antibody
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Catalogue No: abx012210
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US$420.50
(Size: 100 µg)
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Datasheet SDS
Mitogen-Activated Protein Kinase Kinase Kinase 3 (MAP3K3) Antibody is a Rabbit Polyclonal antibody for the detection of MAP3K3. The mitogen-activated protein/ERK kinase kinase 3 (MEKK3) is a member of a family of MEKK/Ste11 serine/threonine protein kinases. One function of MEKK3 is to serve as an upstream regulatory kinase in the mitogen-activated protein kinase cascade, however, it also plays a critical role in other signaling pathways. MEKK3 regulates several important functions including cell survival and proliferation. It is ubiquitously expressed in multiple tissues and has been found in complexes with scaffold proteins and other kinases. (PMID: 18206350).Cerebral cavernous malformations (CCMs) complex regulation of MEKK3 is essential during vertebrate heart development. MEKK3 signalling and KLF2/4 may be targeted to develop new CCM therapeutics.
Research Articles on Mitogen-Activated Protein Kinase Kinase Kinase 3 (MAP3K3)
| Target | Mitogen-Activated Protein Kinase Kinase Kinase 3 (MAP3K3) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/200 - 1/1000, IHC: 1/50 - 1/500. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | mitogen-activated protein kinase kinase kinase 3 |
| Isotype | IgG |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q99759 (UniProt, ExPASy) |
| UniProt Secondary AC | B2RCW2, D3DU15, Q5BKZ6, Q8N3I9 |
| UniProt Entry Name | M3K3_HUMAN |
| Gene Symbol | MAP3K3 |
| GeneID | 4215 |
| OMIM | 602539 |
| HGNC | 6855 |
| KEGG | hsa:4215 |
| Ensembl | ENSG00000198909 |
| String | 9606.ENSP00000354927 |
| Enzyme Commission Number | EC 2.7.11.25 |
| Molecular Weight | Observed MW: 74 kDa |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |