MAP Kinase-Interacting Serine/Threonine-Protein Kinase 1 (MKNK1) Antibody

MKNK1 encodes a predicted 424-amino acid protein containing a sequence typical of the catalytic domain of serine/threonine kinases and a putative N-terminal nuclear localization signal sequence.C-terminal region of MKNK1 was phosphorylated and activated in vivo and in vitro by ERK1 and p38 MAP kinases, but not by JNK/SAPK. The activated ERK is essential for the activation of MKNK1 in insect cells. MKNK1 was activated following stimulation of HeLa cells with a variety of extracellular stimuli. MNK1 bind tightly to the growth factor-regulated MAP kinases, Erk1 and Erk2, and also binds strongly to the stress-activated kinase, p38.

Target	MAP Kinase-Interacting Serine/Threonine-Protein Kinase 1 (MKNK1)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human MKNK1.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9BUB5 (UniProt, ExPASy)
UniProt Secondary AC	D3DQ20, D3DQ21, O00312, Q5TC06, Q5TC07, Q6V0N6
UniProt Entry Name	MKNK1_HUMAN
String	9606.ENSP00000361014
Molecular Weight	Calculated MW: 51.3 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse MKNK1.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on MAP Kinase-Interacting Serine/Threonine-Protein Kinase 1 (MKNK1)

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