MLL Antibody is a Mouse Monoclonal antibody against MLL. Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila). Eukaryotic RNA polymerase II mediates the synthesis of mature and functional messenger RNA. This is a multistep process, called the transcription cycle,that includes five stages: preinitiation, promoter, clearance, elongation and termination. Elongation is thought to be a critical stage for the regulation of gene expression. ELL (11-19 lysine-rich leukemia protein, also designated MEN) functions as an RNA polymerase II elongation factor that increases the rateof transcription by suppressing transient pausing by RNA polymerase II. Also, ELL is thought to regulate cellular proliferation. ELL is abundantly expressed in peripheral blood leukocytes, skeletal muscle, placenta and testis, and has lower expression in spleen, thymus, heart, brain, lung, kidney, liver and ovary.The gene encoding human ELL, which maps to chromosome 19p13.1, is one of several genes which undergo translocation with the MLL gene on chromo-some 11q23 in acute myeloid leukemia. MLL (myeloid/lymphoid leukemia,also designated ALL-1 and HRX) is a 430 kDa protein that regulates embryonal and hematopoietic development.
Target |
Myeloid/lymphoid Or Mixed-Lineage Leukemia (MLL) |
Clonality |
Polyclonal |
Reactivity |
Human, Mouse, Rat |
Tested Applications |
WB |
Host |
Rabbit |
Recommended dilutions |
WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
Conjugation |
Unconjugated |
Immunogen |
Recombinant fusion protein containing a sequence corresponding to amino acids 752-949 of human KMT2A. |
Isotype |
IgG |
Form |
Liquid |
Purification |
Purified by affinity chromatography. |
Storage |
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
UniProt Primary AC |
Q03164 (UniProt,
ExPASy)
|
UniProt Entry Name |
KMT2A_HUMAN |
Gene Symbol |
KMT2A |
GeneID |
4297
|
NCBI Accession |
NP_005924.2
|
KEGG |
hsa:4297
|
String |
9606.ENSP00000436786
|
Molecular Weight |
Calculated MW: 432 kDa Observed MW: 200 kDa |
Buffer |
PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
Concentration |
> 0.2 mg/ml |
Availability |
Shipped within 5-10 working days. |
Note |
This product is for research use only. |
Research Articles on Myeloid/lymphoid Or Mixed-Lineage Leukemia (MLL)