Protein AF-17 (MLLT6) Antibody
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Catalogue No: abx032721
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US$326.25
(Size: 80 µl)
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Datasheet SDS
Protein AF-17 (MLLT6) Antibody is a Rabbit polyclonal against Protein AF-17 (MLLT6). Band 11q23 chromosome locations are associated with approximately 10% of patients with acute lymphoblastic leukemia (ALL) and more than 5% of patients with acute myeloid leukemia (AML). 11q23 translocation associated leukemias typically jointly express lymphoid and myeloid markers and exhibit poor prognosis. The gene at 11q23 involved in the translocations is known by multiple names, including ALL1, HRX, MLL, and TRX1. One of the more infrequent translocations, t (11;17) (q23;q21), MLLT6, encodes a protein of 1, 093 amino acids, containing a leucine-zipper dimerization motif 3-prime to the fusion point and a cysteine-rich domain at the end terminus that can be arranged in 3 zinc fingers. MMLT6 contains amino acid runs associated with domains involved in transcriptional repression or activation. It has been proposed that MLLT6 represses truncated ALL1 function or inhibits function of the normal protein in leukemic cells.
Research Articles on Protein AF-17 (MLLT6)
| Target | Protein AF-17 (MLLT6) |
| Research Area | Infection Immunity |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 1056-1086 amino acids from the C-terminal region of Human Protein AF-17 (MLLT6). |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by saturated ammonium sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P55198 (UniProt, ExPASy) |
| UniProt Secondary AC | Q59F28, Q96IU3, Q9H5F6, Q9UF49 |
| UniProt Entry Name | AF17_HUMAN |
| KEGG | hsa:4302 |
| String | 9606.ENSP00000479910 |
| Molecular Weight | Calculated MW: 112 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |