Matrix Metalloproteinase 14 (MMP14) Antibody
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Catalogue No: abx032725
Price:
US$326.25
(Size: 80 µl)
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Datasheet SDS
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP14 seems to specifically activate progelatinase A, and may thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. Expression is significant in stromal cells of colon, breast, and head and neck.
Research Articles on Matrix Metalloproteinase 14 (MMP14)
| Target | Matrix Metalloproteinase 14 (MMP14) |
| Research Area | Enzymes and Kinases, Metabolic Pathways, Tumor Immunity, Infection Immunity, Cardiovascular Biology, Cancer |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IHC, FCM |
| Host | Rabbit |
| Recommended dilutions | WB: 1/2000, IHC-P: 1/25, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 145-174 amino acids from the N-terminal region of human MMP14. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P50281 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K5L0, Q6GSF3, Q92678 |
| UniProt Entry Name | MMP14_HUMAN |
| NCBI Accession | NP_004986.1 |
| KEGG | hsa:4323 |
| String | 9606.ENSP00000308208 |
| Molecular Weight | Calculated MW: 65.9 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Cow and Pig MMP14. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |