Matrix Metalloproteinase 2 (MMP2) Antibody

Matrix Metalloproteinase 2 (MMP2) Antibody is a Rabbit Polyclonal antibody for the detection of MMP2.

This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.

Target	Matrix Metalloproteinase 2 (MMP2)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	ELISA
Host	Rabbit
Recommended dilutions	Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
Isotype	IgG
Form	Liquid
Purity	≥ 95% (SDS-PAGE)
Purification	Purified by immunogen affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Validity	12 months.
UniProt Primary AC	P08253 (UniProt, ExPASy)
UniProt Secondary AC	B2R6U1, B4DWH3, E9PE45, Q9UCJ8
UniProt Entry Name	MMP2_HUMAN
Gene Symbol	MMP2
GeneID	4313
OMIM	120360
HGNC	7166
KEGG	hsa:4313
Ensembl	ENSG00000087245
String	9606.ENSP00000219070
Molecular Weight	Observed MW: 72 kDa
Buffer	PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration	2 mg/ml
Availability	Shipped within 5-12 working days.
Note	This product is for research use only.

Research Articles on Matrix Metalloproteinase 2 (MMP2)

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