MMP25 Antibody

Catalogue No: abx032731
Price: £25.00
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MMP25 Antibody

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Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, MMP25 is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. In addition, it is thought that this protein is activated intracellularly by furin-like enzymes. This protein activates MMP2 by cleavage. The gene has previously been referred to as MMP20 but has been renamed matrix metalloproteinase 25 (MMP25).

Target Matrix Metalloproteinase 25 (MMP25)
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Tested Applications WB
Recommended dilutions Optimal dilutions/concentrations should be determined by the end user.
Immunogen Human MMP25.
Purification Purified Rabbit Polyclonal Antibody.
Isotype IgG
Conjugation Unconjugated
Specificity This MMP25 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 470-499 amino acids from the C-terminal region of human MMP25.
Storage Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
Swiss Prot Q9NPA2
Buffer PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Availability Shipped within 5-10 working days.
Note This product is for research use only.

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