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Matrix Metalloproteinase 25 (MMP25) Antibody

Catalogue No: abx002193
Price: £120.00
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Matrix Metalloproteinase 25 (MMP25) Antibody Matrix Metalloproteinase 25 (MMP25) Antibody Matrix Metalloproteinase 25 (MMP25) Antibody

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MMP25 Antibody is a Rabbit Polyclonal antibody against MMP25. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25.

Target Matrix Metalloproteinase 25 (MMP25)
Clonality Polyclonal
Reactivity Human
Tested Applications WB, IHC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen A synthetic peptide of human MMP25.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q9NPA2 (UniProt, ExPASy)
UniProt Secondary AC D3DUA8, Q9H3Q0
UniProt Entry Name MMP25_HUMAN
Gene Symbol MMP25
GeneID 64386
String 9606.ENSP00000337816
Molecular Weight Calculated MW: 62 kDa
Observed MW: 76 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration 1.21 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Matrix Metalloproteinase 25 (MMP25) Antibody

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