Matrix Metalloproteinase-7 (MMP7) Antibody

MMP7 Antibody is a Rabbit Polyclonal antibody against MMP7. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.

Target	Matrix Metalloproteinase-7 (MMP7)
Clonality	Polyclonal
Reactivity	Human, Rat
Tested Applications	WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/100 - 1/500. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic peptide corresponding to a sequence within amino acids 50-150 of human MMP7.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P09237 (UniProt, ExPASy)
UniProt Secondary AC	Q9BTK9
UniProt Entry Name	MMP7_HUMAN
Gene Symbol	MMP7
GeneID	4316
NCBI Accession	NP_002414.1
KEGG	hsa:4316
String	9606.ENSP00000260227
Enzyme Commission Number	EC 3.4.24.23 EC 3.4.24
Molecular Weight	Calculated MW: 30 kDa Observed MW: 20-22 kDa/28 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Matrix Metalloproteinase-7 (MMP7)

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