Neutrophil Collagenase (MMP8) Antibody
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Catalogue No: abx027560
Price:
US$326.25
(Size: 80 µl)
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Datasheet SDS
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
Research Articles on Neutrophil Collagenase (MMP8)
| Target | Neutrophil Collagenase (MMP8) |
| Research Area | Enzymes and Kinases, Infection Immunity, Cardiovascular Biology |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 56-84 amino acids from the N-terminal region of human MMP8. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P22894 (UniProt, ExPASy) |
| UniProt Secondary AC | Q45F99 |
| UniProt Entry Name | MMP8_HUMAN |
| Gene Symbol | MMP8 |
| KEGG | hsa:4317 |
| String | 9606.ENSP00000236826 |
| Enzyme Commission Number | EC 3.4.24.34 EC 3.4.24 |
| Molecular Weight | Calculated MW: 53.4 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |