Matrix Metalloproteinase-9 (MMP9) Antibody

MMP9 antibody detects endogenous levels of total MMP9. MMP9 May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide. Belongs to the peptidase M10A family. Activated by 4-aminophenylmercuric acetate and phorbol ester. Exists as monomer or homodimer; disulfide-linked. Exists also as heterodimer with a 25 kDa protein. Macrophages and transformed cell lines produce only the monomeric form. Interacts with ECM1.

Target	Matrix Metalloproteinase-9 (MMP9)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Synthesised peptide derived from human MMP9
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P14780 (UniProt, ExPASy)
UniProt Secondary AC	B2R7V9, Q3LR70, Q8N725, Q9H4Z1, Q9UCJ9, Q9UCL1, Q9UDK2
UniProt Entry Name	MMP9_HUMAN
Gene Symbol	MMP9
KEGG	hsa:4318
Ensembl	ENSG00000100985
String	9606.ENSP00000361405
Enzyme Commission Number	EC 3.4.24.35 EC 3.4.24
Molecular Weight	78 kDa
Buffer	PBS, pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol.
Specificity	MMP9 antibody detects endogenous levels of total MMP9
Concentration	1 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Matrix Metalloproteinase-9 (MMP9)

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