Matrix Metalloproteinase-9 (MMP9) Antibody

MMP9 Antibody is a Rabbit Polyclonal antibody against MMP9. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling.

Target	Matrix Metalloproteinase-9 (MMP9)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic peptide corresponding to a sequence within amino acids 538-707 of human MMP9.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P14780 (UniProt, ExPASy)
UniProt Secondary AC	B2R7V9, Q3LR70, Q8N725, Q9H4Z1, Q9UCJ9, Q9UCL1, Q9UDK2
UniProt Entry Name	MMP9_HUMAN
Gene Symbol	MMP9
GeneID	4318
OMIM	120361
NCBI Accession	NP_004985.2
HGNC	7176
KEGG	hsa:4318
Ensembl	ENSG00000100985
String	9606.ENSP00000361405
Enzyme Commission Number	EC 3.4.24 EC 3.4.24.35
Molecular Weight	Calculated MW: 78 kDa Observed MW: 100/84 kDa
Buffer	PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
Concentration	2.40 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Matrix Metalloproteinase-9 (MMP9)

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