Mouse Stk3 Antibody

Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. MST1/MST2 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1.

Target	Mouse Stk3
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 387-415 amino acids from the C-terminal region of mouse Stk3.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9JI10 (UniProt, ExPASy)
UniProt Secondary AC	Q60877, Q80UG4, Q8CI58
UniProt Entry Name	STK3_MOUSE
String	10090.ENSMUSP00000018476
Molecular Weight	Calculated MW: 56.9 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Rat Stk3.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Mouse Stk3

Write a review

Your Name

Your Email Address

PMID

DOI

Your Review

Rating

Continue