Mouse TSC2 (pS1348) Antibody

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Catalogue No: abx032232
Price: US$326.25
(Size: 80 µl)

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Datasheet SDS
In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity). Specifically stimulates the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. Suggesting a possible mechanism for its role in regulating cellular growth (By similarity).

Target Mouse TSC2 (pS1348)
Clonality Polyclonal
Target Modification Ser1348
Modification Phosphorylation
Reactivity Mouse
Tested Applications ELISA, DB
Host Rabbit
Recommended dilutions DB: 1/500. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1348 of mouse TSC2.
Isotype IgG
Form Liquid
Purification Purified through a protein A column, followed by two-step phosphospecific peptide affinity purification.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q61037 (UniProt, ExPASy)
UniProt Secondary AC P97723, P97724, P97725, P97727, Q61007, Q61008, Q9WUF6
UniProt Entry Name TSC2_MOUSE
String 10090.ENSMUSP00000094986
Molecular Weight Calculated MW: 202 kDa
Buffer PBS containing 0.09% sodium azide.
Specificity Predicted to react with Rat Tsc2.
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Mouse TSC2 (pS1348)


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