Mouse TSC2 (pS1419) Antibody

In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity). Specifically stimulates the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. Suggesting a possible mechanism for its role in regulating cellular growth (By similarity).

Target	Mouse TSC2 (pS1419)
Clonality	Polyclonal
Target Modification	Ser1419
Modification	Phosphorylation
Reactivity	Mouse
Tested Applications	ELISA, DB
Host	Rabbit
Recommended dilutions	DB: 1/500. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1419 of mouse TSC2.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by two-step phosphospecific peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q61037 (UniProt, ExPASy)
UniProt Secondary AC	P97723, P97724, P97725, P97727, Q61007, Q61008, Q9WUF6
UniProt Entry Name	TSC2_MOUSE
String	10090.ENSMUSP00000094986
Molecular Weight	Calculated MW: 202 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Rat Tsc2.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Mouse TSC2 (pS1419)

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