Mouse Wee1 Antibody

Wee1 may act as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur (By similarity).

Target	Mouse Wee1
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 202-230 amino acids from the Central region of mouse Wee1.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P47810 (UniProt, ExPASy)
UniProt Secondary AC	Q9EPL7
UniProt Entry Name	WEE1_MOUSE
KEGG	mmu:22390
String	10090.ENSMUSP00000033326
Molecular Weight	Calculated MW: 71.6 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Rat Wee1.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Mouse Wee1

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