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Protein Zero, Myelin (MPZ) Antibody

Catalogue No: abx001415
Price: £120.00
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Protein Zero, Myelin (MPZ) Antibody

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MPZ Antibody is a Rabbit Polyclonal antibody against MPZ. MPZ (myelin protein zero), also known as P0, a transmembrane glycoprotein (~30 kDa), is a member of the immunoglobulin supergene family. Synthesized by myelin-forming Schwann cells, MPZ is the major structural protein component of myelin in the peripheral nervous system. It is involved in formation and maintenance of compact myelin, and plays a role in the creation of an extracellular membrane face which guides the wrapping process and ultimately compacts adjacent lamellae. More than 120 mutations detected in the gene of MPZ cause various forms of hereditary neuropathy, which include Charcot-Marie-Tooth disease type 1B (CMT1B), CMT2, Dejerine-Sottas syndrome (DSS), and congenital hypomyelination neuropathy (CHN). This antibody can recognize endogenous MPZ, and can be used as a marker of myelinating Schwann cells.

Target MPZ
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein corresponding to human MPZ.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P25189 (UniProt, ExPASy)
UniProt Secondary AC Q16072, Q5VTH4, Q92677, Q9BR67
UniProt Entry Name MYP0_HUMAN
Gene Symbol MPZ
GeneID 4359
OMIM 103100
HGNC 7225
KEGG hsa:4359
Ensembl ENSG00000158887
String 9606.ENSP00000432943
Molecular Weight Calculated MW: 27 kDa, 34 kDa
Observed MW: 27 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration 2.75 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Protein Zero, Myelin (MPZ) Antibody

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