Protein Zero, Myelin (MPZ) Antibody

MPZ Antibody is a Rabbit Polyclonal antibody against MPZ. MPZ (myelin protein zero), also known as P0, a transmembrane glycoprotein (~30 kDa), is a member of the immunoglobulin supergene family. Synthesized by myelin-forming Schwann cells, MPZ is the major structural protein component of myelin in the peripheral nervous system. It is involved in formation and maintenance of compact myelin, and plays a role in the creation of an extracellular membrane face which guides the wrapping process and ultimately compacts adjacent lamellae. More than 120 mutations detected in the gene of MPZ cause various forms of hereditary neuropathy, which include Charcot-Marie-Tooth disease type 1B (CMT1B), CMT2, Dejerine-Sottas syndrome (DSS), and congenital hypomyelination neuropathy (CHN). This antibody can recognize endogenous MPZ, and can be used as a marker of myelinating Schwann cells.

Target	Protein Zero, Myelin (MPZ)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 30-153 of human Myelin Protein Zero (MPZ).
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P25189 (UniProt, ExPASy)
UniProt Secondary AC	Q16072, Q5VTH4, Q92677, Q9BR67
UniProt Entry Name	MYP0_HUMAN
Gene Symbol	MPZ
GeneID	4359
OMIM	103100
NCBI Accession	NP_000521.2
HGNC	7225
KEGG	hsa:4359
Ensembl	ENSG00000158887
String	9606.ENSP00000432943
Molecular Weight	Calculated MW: 28 kDa Observed MW: 28 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	2.75 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Protein Zero, Myelin (MPZ)

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