Macrophage Mannose Receptor 1 (MRC1) Antibody
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Catalogue No: abx216643
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US$420.50
(Size: 100 µg)
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Datasheet SDS
Macrophage Mannose Receptor 1 (MRC1) Antibody is a Rabbit Polyclonal antibody for the detection of CD206. CD206, also named as MMR, CLEC13D and MRC1, is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. CD206 has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment. CD206 is a 170 kDa transmembrane protein which contains 5 domains: an amino-terminal cysteine-rich region, a fibronectin type II repeat, a series of eight tandem lectin-like carbohydrate recognition domains (responsible for the recognition of mannose and fucose), a transmembrane domain, and an intracellular carboxy-terminal tail. It is expressed on most tissue macrophages, in vitro derived dendritic cells, lymphatic and sinusoidal endothelia.
Research Articles on Macrophage Mannose Receptor 1 (MRC1)
| Target | Macrophage Mannose Receptor 1 (MRC1) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/200 - 1/2000, IHC: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | mannose receptor, C type 1 |
| Isotype | IgG |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P22897 (UniProt, ExPASy) |
| UniProt Secondary AC | A5PKW3, Q5VSJ2, Q5VSK2 |
| UniProt Entry Name | MRC1_HUMAN |
| Gene Symbol | MRC1 |
| GeneID | 4360 |
| OMIM | 153618 |
| HGNC | 7228 |
| KEGG | hsa:4360 |
| Ensembl | ENSG00000260314 |
| String | 9606.ENSP00000455897 |
| Molecular Weight | Observed MW: 166 kDa |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |