Double-Strand Break Repair Protein MRE11 (MRE11A) Antibody

MRE11A Antibody is a Rabbit Polyclonal antibody against MRE11A. This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.

Target	Double-Strand Break Repair Protein MRE11 (MRE11A)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 1-302 of human MRE11.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P49959 (UniProt, ExPASy)
UniProt Secondary AC	B3KTC7, O43475
UniProt Entry Name	MRE11_HUMAN
Gene Symbol	MRE11
GeneID	4361
NCBI Accession	NP_005582.1
KEGG	hsa:4361
String	9606.ENSP00000325863
Molecular Weight	Calculated MW: 81 kDa Observed MW: 81 kDa
Buffer	PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Double-Strand Break Repair Protein MRE11 (MRE11A)

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