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Double-Strand Break Repair Protein MRE11 (MRE11A) Antibody

Catalogue No: abx001996
Price: £120.00
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Double-Strand Break Repair Protein MRE11 (MRE11A) Antibody

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MRE11A Antibody is a Rabbit Polyclonal antibody against MRE11A. This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.

Target MRE11A
Clonality Polyclonal
Reactivity Human, Mouse
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human MRE11A.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P49959 (UniProt, ExPASy)
UniProt Secondary AC B3KTC7, O43475
UniProt Entry Name MRE11_HUMAN
Gene Symbol MRE11
GeneID 4361
KEGG hsa:4361
String 9606.ENSP00000325863
Molecular Weight Calculated MW: 77 kDa, 80 kDa, 81 kDa
Observed MW: 90 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Double-Strand Break Repair Protein MRE11 (MRE11A) Antibody

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