G/T Mismatch-Binding Protein (MSH6) Antibody

This gene encodes a protein similar to the MutS protein.In E.coli, the MutS protein helps in the recognition of mismatched nucleotides, prior to their repair.A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs.The encoded protein of this gene combines with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated.Mutations in this gene have been identified in individuals with hereditary nonpolyposis colon cancer (HNPCC) and endometrial cancer.

Target	G/T Mismatch-Binding Protein (MSH6)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC, IF/ICC, FCM
Host	Mouse
Recommended dilutions	ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, IF/ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human MSH6 expressed in E. coli.
Isotype	IgG2a
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P52701 (UniProt, ExPASy)
UniProt Secondary AC	B4DF41, B4E3I4, F5H2F9, O43706, O43917, Q8TCX4, Q9BTB5
UniProt Entry Name	MSH6_HUMAN
Gene Symbol	MSH6
GeneID	2956
OMIM	114500
HGNC	7329
KEGG	hsa:2956
Ensembl	ENSG00000116062
String	9606.ENSP00000234420
Molecular Weight	160 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on G/T Mismatch-Binding Protein (MSH6)

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