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G/T Mismatch-Binding Protein (MSH6) Antibody

Catalogue No: abx002279
Price: £120.00
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G/T Mismatch-Binding Protein (MSH6) Antibody G/T Mismatch-Binding Protein (MSH6) Antibody G/T Mismatch-Binding Protein (MSH6) Antibody

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MSH6 Antibody is a Rabbit Polyclonal antibody against MSH6. This gene encodes a protein similar to the MutS protein. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides, prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein of this gene combines with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene have been identified in individuals with hereditary nonpolyposis colon cancer (HNPCC) and endometrial cancer.

Target MSH6
Clonality Polyclonal
Reactivity Human, Mouse
Tested Applications WB, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/1000, IF/ICC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human MSH6.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P52701 (UniProt, ExPASy)
UniProt Secondary AC B4DF41, B4E3I4, F5H2F9, O43706, O43917, Q8TCX4, Q9BTB5
UniProt Entry Name MSH6_HUMAN
Gene Symbol MSH6
GeneID 2956
KEGG hsa:2956
String 9606.ENSP00000234420
Molecular Weight Calculated MW: 119 kDa, 120 kDa, 137 kDa, 152 kDa
Observed MW: 200 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on G/T Mismatch-Binding Protein (MSH6) Antibody

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