G/T Mismatch-Binding Protein (MSH6) Antibody

MSH6 Antibody is a Rabbit Polyclonal antibody against MSH6. This gene encodes a protein similar to the MutS protein. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides, prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein of this gene combines with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene have been identified in individuals with hereditary nonpolyposis colon cancer (HNPCC) and endometrial cancer.

Target	G/T Mismatch-Binding Protein (MSH6)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	WB, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000, IF/ICC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 1061-1360 of human MSH6.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P52701 (UniProt, ExPASy)
UniProt Secondary AC	B4DF41, B4E3I4, F5H2F9, O43706, O43917, Q8TCX4, Q9BTB5
UniProt Entry Name	MSH6_HUMAN
Gene Symbol	MSH6
GeneID	2956
KEGG	hsa:2956
String	9606.ENSP00000234420
Molecular Weight	Calculated MW: 153 kDa Observed MW: 200 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on G/T Mismatch-Binding Protein (MSH6)

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