Macrophage Scavenger Receptor 1 (MSR1) Antibody

This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.

Target	Macrophage Scavenger Receptor 1 (MSR1)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 336-364 amino acids from the C-terminal region of human MSR1.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P21757 (UniProt, ExPASy)
UniProt Secondary AC	D3DSP3, O60505, P21759, Q45F10
UniProt Entry Name	MSRE_HUMAN
Gene Symbol	MSR1
KEGG	hsa:4481
String	9606.ENSP00000262101
Molecular Weight	Calculated MW: 49.8 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Cow MSR1.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Macrophage Scavenger Receptor 1 (MSR1)

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