Myosin Binding Protein C, Cardiac (MYBPC3) Antibody
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Catalogue No: abx026810
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US$326.25
(Size: 80 µl)
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Datasheet SDS
MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy.
Research Articles on Myosin Binding Protein C, Cardiac (MYBPC3)
| Target | Myosin Binding Protein C, Cardiac (MYBPC3) |
| Research Area | Cardiovascular Biology |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/2000, IHC-P: 1/25. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 189-218 amino acids from the N-terminal region of human MYBPC3. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q14896 (UniProt, ExPASy) |
| UniProt Secondary AC | A5PL00, Q16410, Q6R2F7, Q9UE27, Q9UM53 |
| UniProt Entry Name | MYPC3_HUMAN |
| KEGG | hsa:4607 |
| String | 9606.ENSP00000442795 |
| Molecular Weight | Calculated MW: 141 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Rat MYBPC3. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |