Myc Proto-Oncogene Protein (MYC) Antibody

MYC is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of the gene encoding MYC have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.

Target	Myc Proto-Oncogene Protein (MYC)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 36-65 amino acids from human MYC.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P01106 (UniProt, ExPASy)
UniProt Secondary AC	A8WFE7, P01107, Q14026
UniProt Entry Name	MYC_HUMAN
Gene Symbol	MYC
KEGG	hsa:4609
String	9606.ENSP00000479618
Molecular Weight	Calculated MW: 48.8 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse, Rat, Cow, Pig, Sheep, Zebrafish and Xenopus MYC.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Myc Proto-Oncogene Protein (MYC)

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