Myc Proto-Oncogene Protein (MYC) Antibody

Myc Proto-Oncogene Protein (MYC) Antibody is a mouse monoclonal antibody against Myc Proto-Oncogene Protein (MYC). The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma, in human. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini, in human and mouse. Under conditions of stress, such as high cell densities and methionine deprivation, there is a specific and dramatic increase in the synthesis of the non-AUG initiated protein, suggesting its importance in times of adversity. Alternative splicing results in multiple transcript variants.

Target	Myc Proto-Oncogene Protein (MYC)
Research Area	Tumor Immunity, Cancer
Clonality	Monoclonal
Reactivity	Human
Host	Mouse
Recommended dilutions	Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Storage	Store at 4°C for up to 4 weeks. For long-term storage, aliquot and store at -20°C.
Shelf Life	12 months.
Availability	Shipped within 5-10 working days.
Note	THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.

Research Articles on Myc Proto-Oncogene Protein (MYC)

Write a review

Your Name

Your Email Address

PMID

DOI

Your Review

Rating

Continue