Myc Proto-Oncogene Protein (MYC) Antibody

Myc Proto-Oncogene Protein (MYC) Antibody is a Rabbit Polyclonal antibody for the detection of c-MYC.

MYC contains one basic helix-loop-helix (bHLH) domain. This protein is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. It seems to activate the transcription of growth-related genes. It binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. This antibody is a rabbit polyclonal antibody raised against recombinant protein of human MYC.The 50kDa band recognized by antibody is the native form of MYC, while the other bands, between 60-70kDa, are the phosphorylated form of MYC [PMID: 12189186]

Target	Myc Proto-Oncogene Protein (MYC)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	v-myc myelocytomatosis viral oncogene homolog(avian)
Isotype	IgG
Form	Liquid
Purity	≥ 95% (SDS-PAGE)
Purification	Purified by immunogen affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Validity	12 months.
UniProt Primary AC	P01106 (UniProt, ExPASy)
UniProt Secondary AC	A8WFE7, P01107, Q14026
UniProt Entry Name	MYC_HUMAN
Gene Symbol	MYC
GeneID	4609
OMIM	113970
HGNC	7553
KEGG	hsa:4609
Ensembl	ENSG00000136997
String	9606.ENSP00000479618
Molecular Weight	Observed MW: 50-60 kDa
Buffer	PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration	2 mg/ml
Availability	Shipped within 5-12 working days.
Note	This product is for research use only.

Research Articles on Myc Proto-Oncogene Protein (MYC)

Write a review

Your Name

Your Email Address

PMID

DOI

Your Review

Rating

Continue