N-Myc Proto-Oncogene Protein (MYCN) Antibody

MYCN Antibody is a Rabbit Polyclonal antibody against MYCN. MYCN, also named as BHLHE37 and NMYC, is a transcription factor. It is primarily expressed in normal developing embryos and is thought to be critical in brain and other neural development. It is often amplified in human neuroblastomas. IR34A can suppress MYCN expression, it suggest MYCN has a role in cell growth. The expression of the MCYN is upregulated in a variety of human tumors, most requently neuroblastoma, where the level of expression appearts to increase as teh tumor progress.

Target	N-Myc Proto-Oncogene Protein (MYCN)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/100 - 1/500, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 168-267 of human N-Myc/MYCN.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P04198 (UniProt, ExPASy)
UniProt Secondary AC	Q53XS5, Q6LDT9
UniProt Entry Name	MYCN_HUMAN
Gene Symbol	MYCN
GeneID	4613
NCBI Accession	NP_005369.2
KEGG	hsa:4613
String	9606.ENSP00000281043
Molecular Weight	Calculated MW: 50 kDa Observed MW: 62 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on N-Myc Proto-Oncogene Protein (MYCN)

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