Myosin Light Chain 3 (MYL3) Antibody

Myosins are a large superfamily of motor proteins that move along actin filaments, while hydrolyzing ATP.Myosin is the major component of thick muscle filaments, and is a long asymmetric molecule containing a globular head and a long tail.The molecule consists of two heavy chains and four light chains.Activation of smooth and cardiac muscle primarily involves pathways which increase calcium and myosin phosphorylation resulting in contraction.Myosin light chain phosphatase acts to regulate muscle contraction by dephosphorylating activated myosin light chain.MYL3 encodes myosin light chain 3, an alkali light chain also referred to in the literature as both the ventricular isoform and the slow skeletal muscle isoform.Human myosin light chain has clinical application as a cardiac marker.Mutations in MYL3 have been identified as a cause of mid-left ventricular chamber type hypertrophic cardiomyopathy.

Target	Myosin Light Chain 3 (MYL3)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Mouse
Recommended dilutions	ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of MYL3 expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P08590 (UniProt, ExPASy)
UniProt Secondary AC	B2R534, Q9NRS8
UniProt Entry Name	MYL3_HUMAN
Gene Symbol	MYL3
GeneID	4634
OMIM	160790
HGNC	7584
KEGG	hsa:4634
Ensembl	ENSG00000160808
String	9606.ENSP00000379210
Molecular Weight	22 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Myosin Light Chain 3 (MYL3)

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