MyoGEF Antibody

Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. It Also activates RHOG and does not activate RAC1, or to a much lower extent than RHOA and RHOG. Its part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, It is required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, it is required for normal macropinocytosis.

Target	MyoGEF
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC, FCM
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/50 - 1/100, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 60-87 amino acids from the N-terminal region of human MyoGEF.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q3KR16 (UniProt, ExPASy)
UniProt Secondary AC	Q3SWR1, Q8N1P1, Q8WYY1, Q9H8F4, Q9NVK9
UniProt Entry Name	PKHG6_HUMAN
KEGG	hsa:55200
String	9606.ENSP00000380185
Molecular Weight	Calculated MW: 89 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on MyoGEF

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